One of the more challenging issues that we must address is how do we integrate transformations occurring within the various channels care delivery. For example, in spaces with rising tides, like personalized medicine, there are no real established incumbents; as a result, there appears to be more collaboration. But in established, mature spaces, innovators are trying to truly disrupt the market, and it results in heated tensions between players. So the challenge is how do we facilitate transformation across the whole spectrum? How do we create shared incentives and perspectives, so that incumbents and innovators are working side-by-side to provide the best care possible, while curbing healthcare spending?